Representing over 500 hours of research, the Gene Food Guide to Nutrigenomics was built to catalogue genetic markers that can be influenced by nutrition. Before building the personalized nutrition algorithm we now offer to consumers and health systems, our research team, led by geneticist Dr. Aaron Gardner compiled an exhaustive list of the scientific research in the field of nutrigenomics. Applicable genes were scored based on the state of the scientific evidence with a Science Grade and published, with citations, in the guide. Genes that had sufficient evidence were included in our algorithm and weighted based on strength of research. The guide is updated regularly as new research emerges.
The PCSK9 protein controls the number of low-density lipoprotein (LDL) receptors on the surface of cells. LDL receptors are critical for regulating blood cholesterol levels. The PCSK9 protein waylays LDL receptors after they transport cholesterol into cells, leading to their destruction. This prevents LDL receptors being recirculated back to the cell surface, which means fewer receptors overall and more cholesterol remaining in the bloodstream.