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This enzyme facilitates the breakdown of triglycerides found in circulating chylomicrons and very low-density lipoproteins (VLDL). Consequently, it holds a significant position in clearing lipids from the bloodstream, as well as in the utilization and storage of lipids.

LPL has the ability to bind with lipoproteins, anchoring them to the vessel wall and aiding in the uptake of lipoprotein particles. Additionally, research indicates that LPL plays a crucial role in lipid exchange among lipoproteins, influencing the kinetics of the majority of plasma lipoprotein particles. LPL is also involved in the selective uptake of lipoprotein-associated lipids and lipophilic vitamins without simultaneous uptake of the entire lipoprotein particles.

LPL activity is influenced by insulin. Insulin stimulates LPL, promoting the uptake and storage of triglycerides in adipose tissue. This connection between insulin and LPL is essential for maintaining normal blood lipid levels.


Science Grade
Heart Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs12678919 a g 10

Risk Description

The G allele of rs12678919 correlates with a rise of 2.44 mg/dl in HDL cholesterol, commonly called the “good cholesterol. 1

Recent research in the field of lipidology indicates that elevated HDL, without a corresponding decrease in APOB levels, is not protective against heart disease.

Discuss this information with your doctor before taking any course of action.


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