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MAP kinase-activating death domain protein (MADD) is an adaptor protein encoded for by the MADD gene. MADD interacts with another protein TNF-alpha receptor 1 to activate mitogen-activated protein kinase signaling within cells, in response to apoptotic (controlled cell death) signals, enabling the cell to die in a controlled fashion1.  There is evidence that the SNP rs7944584 is associated with increased circulating glucose levels in man, although a mechanism remains undescribed2.


Science Grade
Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs7944584 a t 17

Risk Description

The risk allele ‘T’ of rs7944584 in the MADD gene has been associated with a decreased conversion of pro-insulin to insulin which leads to higher circulating glucose levels. Interestingly however the risk allele was also associated with markers of improved clinical markers of insulin sensitivity in the same study2,3.

Nutritional Contraindications:*

Ingredient Active Ingredient Effect
High GI Foods

Type 2 diabetes is a disease characterized by high blood sugar levels and varying degrees of insulin resistance and availability.

GI is a measure of how quickly a carbohydrate based food makes blood sugar levels rise after ingestion. There is significant evidence that eating low GI foods (55 and below) 4, especially those rich in fiber can prove beneficial to health 5.

Discuss this information with your doctor before taking any course of action.


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