|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)||Major Amino Acid||Minor Amino Acid|
The mechanism by which the ‘C/G’ allele of C/G66A contributes to an elevated cancer risk is not known, however studies have shown that overexpression of MUC1 can inhibit tumor death and also promote tumor invasion 5,6. Therefore, it is possible to hypothesise that the ‘C/G’ allele of C/G66A is associated with an increased production of Muc1.
Hypomagnesemia is associated with diabetes, high blood pressure and osteoporosis 7,9. Again, no mechanism linking the ‘C/G’ allele of C/G66A with hypomagnesemia been described but if the hypothesis above is correct and the ‘C/G’ allele of C/G66A leads to increased secretion of Muc1, forming a barrier which could then limit magnesium absorption from the gut.
The risk ‘G’ allele of CG66A is associated with hypomagnesemia through an unknown mechanism. Supplementation with magnesium may prove beneficial in correcting this effect.
Discuss this information with your doctor before taking any course of action.