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Heart Health

Cardiovascular disease risk and fat metabolism are determined, in part, by genetics. Below, we list the genetic markers known to play a role in heart health and the nutrients that support the function of each gene.

Heart Health

PCSK9

The PCSK9 protein controls the number of low-density lipoprotein (LDL) receptors on the surface of cells. LDL receptors are critical for regulating blood cholesterol levels. The PCSK9 protein waylays LDL receptors after they transport cholesterol into cells, leading to their destruction. This prevents LDL receptors being recirculated back to the cell surface, which means fewer receptors overall and more cholesterol remaining in the bloodstream.
Heart Health

DHCR7

The DHCR7 gene encodes the enzyme 7-dehydrocholesterol reductase, which is essential for the production of cholesterol.
Heart Health

APOA2

APOA2 is the second most abundant protein found in high-density lipoprotein particles.
Heart Health

PPARG

PPARG is a receptor protein mainly expressed in adipose tissue that regulates glucose metabolsim.
Heart Health

LDLR

LDLR is a receptor protein which specifically recognises LDL particles.
Heart Health

FADS1

FADS1 is an enzyme which desaturates fatty acids by introducing double bonds, an important step in the metabolism of polyunsaturated fats.
Heart Health

CETP

CETP is an enzyme involved in the metabolism of lipoproteins.
Heart Health

CELSR2

CELSR2 is a protein important in cell to cell communication.
Heart Health

APOB

APOB is the main apolipoprotein found in low density lipoproteins, important for carrying dietary lipids through the blood.
Heart Health

AHCY

AHCY is an enzyme which breaks down adenosylhomocysteine into adenosine and L-homocysteine, which are required for several cellular processes.
Heart Health

CPS1

CPS1 is a mitochondrial enzyme involved in the metabolism of proteins and ammonia.
Heart Health

APOE

APOE is an apolipoprotein with a major role in transporting cholesterol in the brain.
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