The ‘C’ and ‘G’ alleles of C-174G are associated with alterations in IL-6 production, both of which are associated with different health risks.
The ‘G’ allele is associated with an increased production of IL-6 compared to the ‘C’ allele 6. This increase in IL6 expression is significantly associated with an increased risk of developing type-2 diabetes 7, particularly in those who are overweight 8.
In comparison the ‘C’ allele is associated with several cardiovascular risks 9, 10. Although a protective effect against the development of juvenile rheumatoid arthritis, which is associated with IL-6, was observed 11.
It is not clear in either case exactly how changes in IL-6 production can influence disease risk.
Nattokinase, the enzyme derived from the Japanese food nattō, has a very strong capacity to break down fibrin blood clots.
As such a beneficial effect on blood pressure 12 and general cardiovascular health has been described 13. Supplementation may therefore prove beneficial in those carrying the ‘C’ allele of C-174G, especially those carrying two copies.
Coenzyme Q10 (CQ10), a naturally occurring coenzyme with numerous health benefits, has been shown to have a positive effect in those with elevated blood pressure 14, however, no effect was seen in healthy controls 15.
Therefore, supplementation may be recommended to those carrying the ‘C’ allele of C-174G, especially to those who carry two copies.
The impacts of a high sodium diet are well established 16.
Therefore, in those carrying the risk ‘C’ allele of C-174G which is associated with several cardiovascular risks, a reduction in sodium intake to recommended levels should be considered.
The ‘G’ allele of C-174G is associated with an increased risk of developing type-2 diabetes. Type-2 diabetes is sometimes referred to as lifestyle diabetes due to its association with common dietary imbalances. For example, consuming too many calories and dietary sugars is strongly associated with development of type-2 diabetes 17.
Discuss this information with your doctor before taking any course of action.