|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)||Major Amino Acid||Minor Amino Acid|
The risk ‘A’ allele of G1958A in the MTHFD1 gene is associated with developmental issues associated with improper maternal folate intake 3. Rather than alter one of MTHFD1’s three enzyme activity the ‘A’ allele is thought to lead to reduced enzyme stability meaning it is degraded more rapidly 4.
There are no described effects in adults so dietary folate supplementation may only be required during pregnancy.
Ensuring a proper dietary intake of folate during pregnancy may therefore be beneficial to those carrying the risk ‘A’ allele.
Discuss this information with your doctor before taking any course of action.