Your Guide to Genetics & Nutrition

Representing over 500 hours of research, the Gene Food Guide to Nutrigenomics was built to catalogue genetic markers that can be influenced by nutrition. Before building the personalized nutrition algorithm we now offer to consumers and health systems, our research team, led by geneticist Dr. Aaron Gardner compiled an exhaustive list of the scientific research in the field of nutrigenomics. Applicable genes were scored based on the state of the scientific evidence with a Science Grade and published, with citations, in the guide. Genes that had sufficient evidence were included in our algorithm and weighted based on strength of research. The guide is updated regularly as new research emerges.

Genes

90+

SNPs

170+

Citations

500+

Gene	Normal Function	SNP ID	Major Allele	Minor Allele
MADD	MADD is thought to regulate controlled cell death but is also implicated in other cellular events.	47336320A>T	a	t
MAOA	MAOA is an enzyme involved in the processing of neurotransmitters, it is sometimes called the "warrior" gene due to proposed links with aggression.	T1410C	c	t
		G1052+680C	g	c
		G891T	t	g
		C306+527T	t	c
MAOB	MAOB is an enzyme involved in the processing of neurotransmitters, it's importance relative to MAOA is under debate.	A1348-36G	a	g
MAT1A	MAT1A is an enzyme responsible for the formation of SAM, a methyl donor molecule key in many other biological processes.	G791A	g	a
MLXIPL	A transcription factor that regulates glycolysis (an cycle of biochemical reactions generating energy from glucose) and lipid production, predominantly in the liver	T73020301C	c	t
MTHFD1	MTHFD1 is an enzyme is an enzyme involved in the conversion of dietary folate into a variety of key products.	G1958A	g	a
MTHFR	MTHFR is an involved in the conversion of dietary folate into a variety of key products.	C667T	c	t
		C117T	c	t
		A1298C	a	c
MTNR1B	MTNR1B is a receptor for melatonin, one of the key sleep hormones.	C2120T	c	t
MTR	MTR is responsible for the regeneration of methionine from homocysteine.	2756A>G	a	g
MTRR	MTRR is an enzyme which helps maintain methionine synthase function, a key component of the methionine cycle.	A66G	a	g
MUC1	Muc1 protein forms part of the protective mucus layer which lines our lungs and digestive system.	C/G66A	a	g
NAF1	NAF1 is a key component of the telomerase enzyme.	n/a	g	a
NOD2	NOD2 plays an important role in the immune system.	C2104T	c	t
NOD2	NOD2 plays an important role in the immune system.	G30491C/T	g	c
NOS3	NOS3 is an enzyme responsible for synthesizing nitric oxide, which is important in many biological processes, especially cardiac function.	G51-898A	a	g
		T894G	g	t
		A-52+1009T	t	a
NQO1	NQO1 is an enzyme with an antioxidant role.	C559T	c	t
PCSK9	The PCSK9 protein controls the number of low-density lipoprotein (LDL) receptors on the surface of cells. LDL receptors are critical for regulating blood cholesterol levels. The PCSK9 protein waylays LDL receptors after they transport cholesterol into cells, leading to their destruction. This prevents LDL receptors being recirculated back to the cell surface, which means fewer receptors overall and more cholesterol remaining in the bloodstream.	E670G	a	g
		V474I	a	g
		R46L	g	t
		L253F	c	t
		G1327A	g	a
		C2037A	c	a
PEMT	PEMT is an enzyme which generates phosphatidylcholine, a key component of cell membranes.	G523A	g	a
PPARA	PPAR-alpha regulates the expression of genes involved in multiple steps of lipid metabolism, glucose metabolism, and energy homeostasis, and in addition it plays a role in the inflammatory process and vascular function.	L162V	c	g
PPARG	PPARG is a receptor protein mainly expressed in adipose tissue that regulates glucose metabolsim.	68777C>G	c	g
SLC2A14	SLC2A14 is a transporter protein which shuttles glucose into cells.	A8025266G	a	g
		C8008132A	c	a
		C8023530T	c	t