|Minor Allele Frequency (%)
|Major Amino Acid
|Minor Amino Acid
The risk ‘T’ allele of C559T in the NQO1 gene is associated with an increased overall cancer risk 5. It is thought this is driven by structural changes, induced by the inclusion of a serine rather than a proline amino acid with the risk ‘T’ allele, leading to a loss of enzyme activity due to a poorer association between NQO1 and its vitamin B2 cofactor 6. This loss of enzyme activity reduces the antioxidant capacity of the body increasing the risk of cancer, and leading to a poorer prognosis post diagnosis 7,8.
Vitamin B2 is a cofactor for NQO1, and is required for it to function correctly 9.
Therefore, supplementation may benefit those carrying the risk ‘T’ allele of C559T, which is associated with impaired co-factor binding. Ensuring a proper supply of vitamin B2 will ensure that this is not the limiting factor for NQO1 activity.
The risk ‘T’ allele of C559T is associated with a poorer antioxidant capacity which may be associated with a reduction in intracellular glutathione, a potent antioxidant 10.
Glutathione supplementation may therefore benefit those carrying the risk ‘T’ allele of C559T.
Discuss this information with your doctor before taking any course of action.