SLC2A14

Protein:

Solute carrier family 2 member 14

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Glucose/dehydroascorbate transporter (GLUT14) is a cell membrane protein that transport sugars such as glucose and fructose into cells, and is encoded for by the SLC2A14 gene. Although information on the gene is limited, it is thought to transport glucose and dehydroascorbic acid (a form of vitamin C) into cells, and distinct variants have been described showing different levels of function 1.

Similar proteins to GLUT14 with SNPs are associated with the development of inflammatory bowel disease (IBD), along with a lack of proper dietary antioxidant take up, especially of vitamin C 2,3,4.

A8025266G

Science Grade
B-
Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs10846086 a g 13

Risk Description

The risk allele ‘G’ of the SNP rs10846086 in the SLC2A14 gene has been associated with an increased risk of developing ulcerative colitis and Crohn’s disease in a single study, along with rs2889504 and rs12815313.

The authors propose that this effect is driven by a reduction in the amount of vitamin C absorbed by the cells lining the gut, which leads to a lack of antioxidant activity 5.

Direct Nutrients:*

IngredientActive IngredientEffect
Vitamin C Ascorbic acid

Vitamin C is a potent antioxidant important in many tissues throughout the body 6.

Supplementation may therefore benefit those carrying the risk ‘G’ allele of the SNP rs10846086, which is associated with impaired vitamin C uptake in the gut, and the development of IBD.

Discuss this information with your doctor before taking any course of action.

C8008132A

Science Grade
B-
Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs2889504 c a 10

Risk Description

The risk allele ‘A’ of the SNP rs2889504 in the SLC2A14 gene has been associated with an increased risk of developing ulcerative colitis and Crohn’s disease in a single study, along with rs10846086 and rs12815313.

The authors propose that this effect is driven by a reduction in the amount of vitamin C absorbed by the cells lining the gut, which leads to a lack of antioxidant activity 5.

Direct Nutrients:*

IngredientActive IngredientEffect
Vitamin C Ascorbic acid

Vitamin C is a vital antioxidant used by a variety of tissues throughout the body to prevent oxidative stress 6.

Supplementation may therefore benefit those carrying the risk ‘A’ allele of the SNP rs2889504, which is associated with impaired vitamin C uptake in the gut, and the development of IBD.

Discuss this information with your doctor before taking any course of action.

C8023530T

Science Grade
B-
Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs12815313 c t 37

Risk Description

The risk allele ‘T’ of the SNP rs12815313 in the SLC2A14 gene has been associated with an increased risk of developing ulcerative colitis and Crohn’s disease in a single study, along with rs2889504 and rs10846086.

The authors propose that this effect is driven by a reduction in the amount of vitamin C absorbed by the cells lining the gut, which leads to a lack of antioxidant activity 5.

Direct Nutrients:*

IngredientActive IngredientEffect
Vitamin C Ascorbic acid

Vitamin C is an antioxidant which is used throughout the body to prevent against oxidative stress 6.

Supplementation may therefore benefit those carrying the risk ‘T’ allele of the SNP rs12815313, which is associated with impaired vitamin C uptake in the gut, and the development of IBD.

Discuss this information with your doctor before taking any course of action.

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