KLOTHO-VS Report Now Available for Health Intelligence Members!


Not sure what to eat?

Get a custom nutrition plan.

Start Here

Apolipoprotein C3 (APOC3) is a protein primarily involved in lipid metabolism and the regulation of triglyceride levels in the bloodstream. APOC3 inhibits the activity of lipoprotein lipase, an enzyme responsible for breaking down triglycerides in circulating lipoproteins.

By inhibiting LPL, APOC3 reduces the clearance of triglyceride-rich particles, leading to elevated triglyceride levels in the blood. APOC3 also plays a crucial role in regulating the metabolism of various lipoproteins, including very-low-density lipoproteins (VLDL) and chylomicrons. 


Science Grade
Heart Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs5128 c g 10.7

Risk Description

Individuals with GC/GG genotypes and diabetes exhibit significantly higher levels of triglycerides (1.91 vs 1.62 (mmol/L)^2) (p=0.004), total cholesterol (4.67 vs 4.29 (mmol/L)^2) (p=0.003), and glucose (8.74 vs 7.91 (mmol/L)^3) (p=0.016) when compared to CC subjects. 1

Discuss this information with your doctor before taking any course of action.


Get the very latest on genetics, nutrition and supplements delivered to your inbox

Facebook icon Twitter icon Instagram icon Pinterest icon Google+ icon YouTube icon LinkedIn icon Contact icon Info icon Email icon Phone icon Pin icon
Back to top