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APOC3

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Apolipoprotein C3 (APOC3) is a protein primarily involved in lipid metabolism and the regulation of triglyceride levels in the bloodstream. APOC3 inhibits the activity of lipoprotein lipase, an enzyme responsible for breaking down triglycerides in circulating lipoproteins.

By inhibiting LPL, APOC3 reduces the clearance of triglyceride-rich particles, leading to elevated triglyceride levels in the blood. APOC3 also plays a crucial role in regulating the metabolism of various lipoproteins, including very-low-density lipoproteins (VLDL) and chylomicrons. 

40G>C

Science Grade
A+
Heart Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs5128 c g 10.7

Risk Description

Individuals with GC/GG genotypes and diabetes exhibit significantly higher levels of triglycerides (1.91 vs 1.62 (mmol/L)^2) (p=0.004), total cholesterol (4.67 vs 4.29 (mmol/L)^2) (p=0.003), and glucose (8.74 vs 7.91 (mmol/L)^3) (p=0.016) when compared to CC subjects. 1

Discuss this information with your doctor before taking any course of action.

Sandeep Grover

Being a geneticist with a statistical background, I have been actively involved in studying influence of epidemiology and genetics on disease susceptibility and drug response. I hope to be counted in my field with a strong background in epidemiology, statistics and clinical research. My current interest include use of sequencing and Mendelian Randomization to unearth causal association of biomarkers.
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