|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
There is some evidence that the risk ‘T’ allele of C-590T in the GCLM gene is associated with impaired clearance of mercury which is a potent oxidant 3.
Mercury is typically eliminated from the body by antioxidants such as glutathione. However, in those carrying the risk ‘T’ allele, with an increased effect seen for those carrying two copies, increased retention of mercury was detected.
The authors of the study hypothesize that this is due to reduced glutathione synthesis in the body however no data has yet been provided to demonstrate this.
|Avoid mercury containing foods|
Mercury is a well known toxin and so should be largely absent from the food chain.
Unfortunately due to increasing environmental pollution and the relative persistence of mercury in plants and animals it is known to bio-accumulate rapidly. Therefore those carrying the risk ‘T’ allele of C-590T may wish to avoid foods in which bio-magnification of mercury levels has occurred, such as certain fish and other apex predators 4.
Discuss this information with your doctor before taking any course of action.