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Glutathione supplements: everything you need to know

Article at a Glance
  • Glutathione is an “endogenous antioxidant,” meaning it is made by our bodies, but stress, toxins and periods of illness can all deplete glutathione levels.
  • Oral glutathione supplements are poorly absorbed, however, N-acetyl-cysteine, or NAC, can help restore glutathione after a life event has depleted glutathione. NAC is only effective at restoring depleted glutathione, not at building or maintaining normal levels.
  • Because glutathione supplements aren’t well absorbed, many people turn to IV therapy. Glutathione IV therapy can cause bad reactions, sometimes called Herxheimer reactions, in people with chronic illness, genetic polymorphisms that alter sulfur metabolism, or when doses are just too high.
  • If you’re considering glutathione IVs, start out at a small dose of below 500 mg, and know the status of your CBS genes before starting the protocol.
Genes Mentioned
glutathione dosage

A couple years ago now, I attended the Institute for Functional Medicine annual conference in San Diego, close to where I used to live in La Jolla. One of the things that struck me about the conference was how often glutathione was mentioned, both in the lectures, as well as among exhibitors. In my notes, I wrote “glutathione, turns off inflammation,” right next to my notes on Omega 3 vs. Omega 6 ratios.

In fact, there was an IV station right in the exhibitor hall that offered IV therapy, glutathione being one option.

Glutathione is all the rage in the supplement world, but what is it?

What is glutathione?

Glutathione has been called the “mother of all antioxidants,” and is lauded for its detoxification abilities.

According to Dr. Mark Hyman:

Glutathione is a very simple molecule that is produced naturally all the time in your body. It is a combination of three simple building blocks of protein or amino acids — cysteine, glycine and glutamine. The secret of its power is the sulfur (SH) chemical groups it contains. Sulfur is a sticky, smelly molecule. It acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals. Normally glutathione is recycled in the body — except when the toxic load becomes too great…

Glutathione is an endogenous antioxidant, which means our bodies produce it naturally, but like many other processes, our ability to utilize glutathione is impacted by environment. (R) Stress, toxicity, NSAID use, or illness can lower our glutathione levels, and ultimately, degrade our health.

One of the reasons I am interested in glutathione is because of research I’ve done on the SOD2 A16V gene, and how certain variants of the gene carry lower levels of superoxide dismutase (SOD2), another endogenous antioxidant responsible for clearing free radicals. If levels of SOD2 are reduced, antioxidant activity from other sources becomes that much more important.

See also: Why I removed my dental amalgams for a discussion on mercury, genetics, and toxicity.

Can glutathione supplements be absorbed?

Oral glutathione supplementation has traditionally been viewed as less effective because it was not able to be absorbed as readily into the blood, however, recent studies demonstrate that human subjects can absorb, and benefit from, glutathione in what is known as liposomal form, meaning it’s encased in a type of fat. (R) As a general rule, I am not a big fan of liposomal supplements because the phospholipids used to encase the desired nutrient can have negative health consequences independent of the focus of the supplement. I’ve written about this in the context of curcumin supplements. Curcumin is often paired with fats, like phosphatidylcholine, in order to improve bioavailability. However, what most people don’t know is that phosphatidylcholine, lecithins, and other phospholipids increase levels of a gut metabolite known as TMAO, which has been linked to heart disease. So, although phospholipid encased glutathione supplements increase absorption of glutathione, they may also be bad for your heart at the same time. 

Choosing a glutathione supplement

In light of the poor bioavailability of glutathione supplements, the trick is navigating the additives supplement manufacturers add to products to make their formulas more readily absorbable. In almost every case, the oral glutathione supplements available to consumers use some form of lecithin, either sunflower or soy derived.

Glutathione supplement comparison

Nordic Naturals Omega CurcuminFish150 mg L-glutathione60/ct
Seeking Health Optimal Liposomal GlutathioneSunflower500 mg L-glutathione30/ct
Pure Encapsulations Liposomal GlutathioneSoy/extra-virgin olive oil250 mg Setria glutathione60/ct
ReadiSorb Liposomal GlutathioneSoy422.7 mg reduced glutathione4 fl oz

Optimal Liposomal Glutathione by Seeking Health (Not recommended)

For example, Optimal Liposomal Glutathione by Seeking Health contains 400mg of phosphatidylcholine in addition to 500mg of glutathione. That is a big dose of sunflower-derived phospholipids. Some in the functional health community advocate for phosphatidylcholine supplementation, especially in the presence of mutations in the PEMT genes, but I am skeptical.

As I mention above, there is good data suggesting that phosphatidylcholine is metabolized in the gut into TMAO. The only way I would take a supplement so heavy in phospholipids on a regular basis is if I knew my serum TMAO levels, and I don’t. We know the body’s ability to clear TMAO varies by genotype, but I also don’t know of a single person who is regularly testing for TMAO. Furthermore, one of the primary reasons for taking glutathione is to quell inflammation, but the sunflower derived phosphatidylcholine blend used by Seeking Health is loaded with inflammatory omega-6 fats, and we know that one of the drivers of inflammation is more omega 6 fatty acids than omega 3 fatty acids. (R) In summary, I like the bioavailability of the glutathione, I just don’t like all the other gunk you have to ingest to get it in your system.

Other products that are very similar to Seeking Health are Pure’s liposomal glutathione and ReadiSorb, which is liked by many in the health care industry.

Omega Curcumin with Glutathione by Nordic Naturals (Recommended)

I added Omega Curcumin by Nordic Naturals to my Omega 3 Fish Oil guide as well, and even gave it an A- rating, which will likely confuse some people. After all, this is a post about glutathione, not curcumin. However, in addition to 400mg of curcumin, the Omega Curcumin product contains 150mg of glutathione for every two capsules, and the best part is that the glutathione is encased in a high quality, omega-3 fish oil rather than a sunflower lecithin. Nordic Naturals adds N-acetyl-cysteine (NAC) to the formula to complete, what is in my view, a very high quality product.

I will get into glutathione dosing later in this post, but although some people will view it as too small, I think 150mg of glutathione is a nice starter dosage for people getting started with glutathione. It’s unlikely most people will have major detox reactions at 150mg. 

IV glutathione – Mixed reactions

It’s no coincidence that glutathione IVs are often administered to people who are suffering from serious illness, such as lyme, cancer and HIV patients. In fact, among other illnesses, such as cancer, cardiovascular disease, and even cystic fibrosis, glutathione deficiency is linked to poor survival rates in HIV patients, showing the link between healthy glutathione levels and immune function. (R) (R

When I began researching glutathione online, I came across a number of Lyme disease forums discussing different experiences with IV therapy, but not many from healthy people who have experimented with glutathione as a means to bolster antioxidant activity. 

For example, this Lyme disease forum thread discusses glutathione induced “Herx” after taking an IV. Herx is short for what is known as a Herxheimer reaction, the process of bacteria dying off after treating Lyme disease with antibiotics. Many Lyme disease patients describe Herx like symptoms after taking glutathione intravenously. I’ve included a snippet from one of the threads below:

Not the orals, that I’ve noticed, but the IVs cause me to herx (at least I believe it’s a herx), usually lasts a day or two and I feel extremely tired and usually very emotional. Then I usually feel much better by the 2nd or 3rd day. My integrative doctor told me that these could definitely cause a herx because it’s boosting the immune system and removing toxins.

Since the internet is lacking information on this topic, and since glutathione therapy is likely to continue growing in popularity, I am sharing my experience with a 1,200mg IV dose I took a couple days ago. Note: 1,200 mg is a very high glutathione dosage — I would recommend starting much smaller, with a 200mg dose to see how your body reacts. This is why I think the Omega Curcumin product by Nordic Naturals is such a good option.  

My experience with glutathione IV therapy

When I take a B vitamin shot, I feel an energy surge, sometimes for days after, but glutathione produced the opposite result for me. Again, I do not have Lyme disease (recently tested negative in a comprehensive blood panel), but I did feel similar symptoms to the Herx reaction described in the Lyme forums at the 1,200mg mega glutathione dose.

The doctor who administered the IV told me I could expect to feel euphoric after taking glutathione, but that wasn’t my experience, except for maybe 10 minutes of mild euphoria toward the end of the IV. Instead, I felt very calm. I felt a cessation of my normal workplace concerns, and felt generally at ease, but not as though I’d taken some type of sedative — just less concerned than usual, perhaps more centered. I would compare the feeling with how I’ve felt after finishing a month-long liver detox.

Two hours after the IV

About two hours after the IV, I felt fatigue, so much so that I took a long afternoon nap. When I woke up, I still felt groggy and just generally “off.” I took my dog for a walk and although the walk wasn’t strenuous, I didn’t feel like my normal energetic self. Slightly light headed. When I came home, I still felt withdrawn, with low energy, and the best I can do to describe my mental state would be to say I was “out of it,” but not in an extreme way — it was subtle. A low-level malaise had set in.

The day after

The next day, I still felt off. I’d say it was like I was in the mood for a form of hibernation, but not a happy one, an unsettled hibernation, like as if I had been separated from my bear wife and was kind of down about it. Add to that feeling unusually emotional, which is consistent with the Herx reactions described on the Lyme forums. I felt sad, down, and still tired. I took another nap in the afternoon, for a good hour and a half. Did a cardio workout to snap out of it, and that seemed to help, but it didn’t bring me all the way back.

Two days later

Woke up feeling clear, feeling great. Much improved and alert, the lingering melancholy/hibernation feeling largely gone; however, toward the end of the second day I still had some unusual fatigue. 

Three days after and beyond

It’s now been 4 days since my shot, and I’ve napped every day since taking the IV. Each day I wake up feeling better and more energetic, but still feel lower energy than usual in the afternoons. Workouts seem to snap me back to my normal energy levels, which are usually high. Even fours days after, I still felt the lingering effects of being slightly more down than I’m used to, but to be fair, the feeling is subtle, not overwhelming.

I’m finishing up this portion of the blog one week after taking the glutathione IV. As I write this, I feel good, back to my normal self.

However, I have had more fatigue this week than I normally would. I haven’t felt sick, just more prone to an afternoon nap than most days. Toward the end of the week, I traveled to the east coast and have some jet lag. I also arrived in a state where everything is in bloom and my allergies are going a bit haywire, so both of those changes could be a factor.

In sum, as a healthy person taking glutathione, I did not experience euphoria at the 1200mg glutathione dosage; instead, I felt tired and emotional immediately after taking the IV. That quickly faded, and left in its wake a low-level fatigue that decreased in intensity each day until it went away completely.

Months later – experiment #2 – Lower glutathione dosage and Vitamin C IV

Again, after researching SOD A16V mutations, I was making a conscious effort to include glutathione in my supplement regimen. However, after having labs done and finding that my serum glutathione levels were normal, I don’t go for glutathione IVs as often as I used to. Instead, if I’ve had a big night out, I will supplement with N-acteyl-cysteine, which is a glutathione precursor.

For more, see: Supplements to use for avoiding a hangover

Are certain genotypes sensitive to glutathione?

The primary glutathione producing gene is GSTP1.

Variants of this gene (rs1695 G and rs1138272 T), which result in greater glutathione activity, have been associated with lower mercury levels.

However, it’s not the GSTP1 gene that is our focus at present, but instead genes related to sulfur metabolism.

Let’s focus again on the quote from Dr. Mark Hyman at the beginning of this post: “the secret of glutathione’s power is in the sulfur chemical groups it contains.”

When you take glutathione, you also take the sulfur compounds it binds to, and emerging research is showing us that people metabolize sulfur differently based on their genes.

Lower levels of CBS – not sensitive to glutathione

The bottom line is that an enzyme called cystathionine beta synthase (CBS) is responsible for breaking down homocysteine (an amino acid linked to heart disease) and converting it to cystathionine. (R) This is the first step in a metabolic process called the transsulfuration pathway. Mutations in the CBS genes which lower levels of the enzyme, have been linked to conditions like hyperhomocysteinemia and homocystinuria. (R) CBS deficiency causes poor metabolism of sulfur groups, causing them to “pool,” and homocysteine levels to rise. In these situations, supplementing with N-acetyl-cysteine (a precursor to glutathione) has shown promise. (R)

Up-regulated CBS potentially sensitive to glutathione – not conclusive

However, some mutations can go in the opposite direction, and cause an “up-regulation” of sulfur activity. These are the mutations that can supposedly cause sensitivity to sulfur donor supplements like glutathione. The research seems to show that the most critical gene determining this type of sulfur sensitivity is CBS C699T, with A as the risk allele. What happens here is the opposite of the low CBS situation where homocysteine is converted too slowly to cystathionine, instead, homocysteine is converted too quickly. The resulting issues can be excess ammonia and sulfites, both of which are toxic to the body and can create symptoms such as anxiety, lethargy, high cortisol, and ADHD.

Alcohol and Tylenol deplete glutathione – N-acetyl-cysteine rebuilds

Science Score:

The two most common substances that deplete glutathione are alcohol and acetaminophen. (R) (R) So, you’ve had a night our drinking, or maybe a few nights, is there a supplement you can take to restore glutathione levels?

The beginning of the post describes glutathione as an “endogenous antioxidant,” which means it’s made by our bodies without supplements. However, there are available supplements like N-acetyl-cysteine, which are direct precursors to glutathione, and can he helpful in restoring glutathione levels after they’ve been depleted. (R(R) (R) (R

This study in the European Journal of Clinical Pharmacology had this to say about N-acetyl-cysteine:

N-acetyl-cysteine had no effect on plasma glutathione in the absence of increased stress on the glutathione pools. However, NAC supports glutathione synthesis when the demand for glutathione is increased, as during the metabolism of paracetamol.

The bottom line

Whether you have a good experience with glutathione supplements depends on a number of factors, such as the state of your overall health, dosage, whether you have a build of toxins in your system, and the state of your genetics.

It is possible to “Herx” from a large dose of glutathione, but if you have a bad reaction, it could also be that you don’t tolerate sulfur donor supplements well.

The biggest thing I learned is to take it slow. I don’t recommend jumping right in with a 1,20mg IV dosage.

Feel free to leave your experiences in the comments.

John O'Connor

John O'Connor is the founder of Gene Food and an Integrative Health Coach, trained at Duke IM. He lives in Austin, Texas.

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  1. Maddy says:

    Hi, thanks so much for this post!!! I am “GG” for CBS C699T, but am homozygous for CBS A360A “AA”. Trying to figure out if this is slow or fast? Somehow it is associated with mast cell issues. Also have SOD3 rs2855262, “CC” which is homozygous for the risk allele.

  2. Hey Maddy, thanks for the comment. The CBS A360A gene is thought to be up-regulated, or “fast,” meaning carriers could theoretically have low homocysteine or high serum ammonia. Take a look at our CBS gene page for more information. The link with CBS A360A and non-Hodgkin lymphoma is very weak at best.

  3. Ty says:

    You are right! My herx usually doesn’t last that long, maybe a day or two. I feel extremely malaise shivering cold lethargic as can be. But then I guess I should I take anywhere from 4000 to 6000mg iv. After a couple of hours everything gradually starts to shift back to normal.

  4. Ty says:

    lol,Yes It does put me to bed with a chivering coldness, but by 5 hours I’m back to normal and I feel great today. I started with a little over 2000mg then 4000 and so on yesterday I tried 6000 ,but I want go higher lol.

  5. Lgordon says:

    glutathione and methylfolate supplement reactions have been debilitating.
    I had 2 acute reactions with the following symptoms. sudden onset of uncontrollable weeping and sadness-confusion-clumsy-imbalanced. niacin helped.
    These symptoms although much less severe are ongoing though transient.
    I have found nothing on the internet as to why this happened to me and
    how I can heal. my memory is in the toilet-and I have a difficult time remembering
    even the most common words. I have to concentrate sometimes to walk with a normal gait.
    any insights?
    fyi-the glutathione I took was reconcastat oral powder in an initial small dose and not in conjunction with the methylfolate. that was a separate incident.
    Im compound heterozygous MTHFR

    • Lynda,

      Thank you for the comment. Unfortunately, getting a protocol setup for you that you will be able to tolerate is beyond the scope of this post, and is a question for your doctor, however, I can say that, as this post points out, people, including myself, do sometimes react to glutathione supplements. Oral glutathione supplements are poorly absorbed and, at a small dose, it may have been something else that brought on your symptoms. Have you had your serum glutathione levels checked? If they are normal, supplementing with glutathione may not be necessary at all. You may also want to discuss your CBS status with your doctor. If you have SNPs in that region, you could be sensitive to sulfur donors in general. Hope this helps!

      • Cindy says:

        I have both the CBS C699T and the A360A +/- I have been taking glutathione as my functional practitioner said I was low. I have been using the sublingual drops by Quicksilver. This morning I woke up feeling fine and went into the kitchen to take them and right after taking my Gaba drops and Thrn glutathione I felt incredibly dizzy and unstable. No vertigo-hard to explain though. Started praying and held onto the counter top and came and sat down. I wish I could clear it out. Maybe I will take charcoal. Not sure if I am sensitive to sulfur donors but I do tend to run higher homocysteine and sometimes high CRP and other inflammatory markers. But at times they seem to fluctuate high and then normal the next time. I wish I could understand all of this but definitely don’t want to repeat this dizziness. Thanks for any suggestions you may have.

  6. dana says:

    Hi, I am wondering how to find out what my gene makeup is to be able to determine if I could be sensitive to sulfur. Would like that answered first, but I am doing this on my own. I was treated for Lymes and knew I needed much detoxing and still do. However, after treatment, I found it difficult to take liposomal glutathione. For sure herxing, feeling more aches and pain and it really messed with my bowels. Horrible! I tried NAC and it just gives me the worst lower belly ache and also messes with my bowels.Even more horrible! I let a year and a half pass and just took whey protein on most mornings during that time. That worked. Then recently, I added liposomal Vit C for 3 months and really liked the results of that. I just started taking liposomal glutathione, titrating up to a full dose, but not liking how it feels at this level. It messes with my bowels (really constipates me). If I take too much I do get lethargic and in a mood very similar to what you described. So, I am going to keep the glutathione down to half a dose, and restart the liposomal C to a full dose. What do you think?

    • Dana, you can find your genotype for the CBS genes (sulfur metabolism) by taking the raw data from 23andme to a site like Livewello. I can’t comment on whether you should or should not be taking any of the supplements listed because I am not your doctor, but there is no mandate that anyone take glutathione or any other supplement. If it makes you feel repeatedly ill, don’t take it. Liposomal supplements are “wrapped” in beads of fat, often Phosphatidylcholines, which I avoid because of studies that show they are metabolized into TMAO, a lipid metabolite associated with heart disease. Liposomal supplements are often very high in omega 6. For more on that, check out this post:

  7. Ty says:

    You guys got my attention the term sensitive to sulfur is new to me in that sense, As I am allergic to Sulfur antibiotics. But natural occurring sulfur I am not so I can dose glutathion in high doses and I also take MSM which is sulfur related. The natural occurring sulfur that takes place in the body is not a issue for me but I don’t no about others. Just a thought

    • Anne says:

      Thanks for the post about Sulpha drugs. I also cannot tolerate them and wondered about increasing. Sulphur with glutathione. I also cannot tolerate soy, so the liposomal formula that the doctor gave me for inflammation is causing problems. I already take NAC, omega 3, and curcumin, many other supplements. I have the methylating gene (MFTHR?) and Lyme for 40+ year’s, etc. I’m still unsure which glutathione to take for the “inflammatory state” he determined I am in now.

  8. LK says:

    Hi! I’m started taking 1200 mg glutathione supplement for 2 weeks now. I’ve noticed I’m always tired and I can’t control my sleepiness. Also, my whole body started to ache like I just started working out the first time. Is this normal or is my body telling me to stop taking them?

  9. Tahra says:

    Hi there. Great info especially on how to use the 23 and me info. But I am curious about the product thorne glutathione – S are. Is that like the liposomal version?

  10. Tahra says:

    Hi there sorry for my previous email I figured out how to upload the raw data from 23 and me. So I ran a report on live well low and got this “CBS C699T rs234706 is AG A chromosome from one parent, carries the genetic variation which is determined by the presence of the variant allele A. What does that mean? I am sensitive to sulfur? Sorry biology was never a strength in school!

    • Impossible to say over the internet, probably a question for a doc who knows nutrigenomics. Based on one copy of one SNP though I wouldn’t worry too much. Watch how your body reacts to sulfur and sulfur donor supplements, like NAC and glutathione.

  11. Jay says:

    What about glutathione suppositories? Or coffee enema’s for liver detox? I was diagnosed with fatty liver and am trying to get fat out of liver along with protect it from damage. Thanks

    • MPH says:

      I wonder the same. John, could you please commend on this? There are Liposomal Glutathione in suppositories they supposed to go straight to your liver. What are you thoughts on this? I hope you reply back.

  12. Sandeep says:

    Hi. Quite an interesting reading. My father has Idiopathic Parkinsons. What’s the best form of GSH for his brain ? Nasal, Oral or IV ?

    Thanks a lot

    • Hey Sandeep, over and above what I have shared here, I am not sure about glutathione for your father’s condition. Probably a question best suited for his doctor. Having said that, for my own personal use, I stay away from the liposomal products and instead currently use the Omega Curcumin and occasional (as in once a year) IV glutathione. Were I to use liposomal, it would be for short bursts, not for long term usage. Again, I am not versed in treating Parkinson’s and am not a doctor, so I couldn’t say how best to tackle your Dad’s supplements. If the doctor weighs in, I’m sure our readers would be curious to know what his or her input was. Good luck and thank you for reading.

  13. AnnettePK says:

    Any thoughts on S-Acetyl L Glutathione? I’ve been taking the Redisorb Glutathione for over 10 years, 400-1200mg/day. It helps enormously with symptoms of Lyme and chronic fatigue. The first time I took glutathione was an IV about 15 years ago. By the end of the day I realized I was not nearly as tired as I usually was. I also felt like I was NOT being poisoned for the first time in years.

  14. R.Dorrie says:

    I take 2, 2000 mg of Glutathione injections per day and take 500 mg Liposomsal Glutathione pill every hour just to detox. People exposed to high levels of toxins need at least this much. At clinic, I got 20,000 to 40,000 mg injected into my port per day and peed out crazy amounts of toxins. Any side effect you have is because you desperately need it.

  15. Lotaz says:

    Hello, I want to ask about LivOn labs liposomal glutathione. Is it good and safe? Actually I’m using it with liposomal vi c and Acetyl-L-Carnitine capsules. I just heard that liposomal the best in absorption I have not idea about side effect.

  16. K says:

    Thank you for this post! I heard about glutathione from a nurse I met in Seattle. She is from the Philippines and has a side business there administering glutathione in IV form to her clients. She says she feels the ideal dose is 2 500mg vials per treatment over 5 treatments. She said she has seen glutathione clear up her son’s cystic acne, cure her husband’s gout, and heal her brother’s rotator cuff injury. All these reports sounded too good to be true, but I got my boyfriend to try it to see if it would help with his chronic pain and inflammation caused by 2 herniated cervical discs and/or his full thickness tear of his supraspinatus in his right arm. We are both photographers and shoot daily at our jobs with a fashion retail company. At his first glutathione IV push he was given 500mg of glutathione followed by 3mg vitamin C. He experienced pain in his forearm during the treatment and later the pain spread to his shoulder and mostly his teres minor but all the trigger points related to his rotator cuff hurt. Prior to the treatment, he felt okish. The pain lasted for 3 days and he didn’t take any Tramadol during those days either. On the fourth day, he gave in and took 1-50 mg Tramadol and was doing much better. The same thing happened after his second (and probably final) treatment where he was given 600mg of glutathione and 3mg of vitamin C. (I tried it too and had no adverse reaction, no noticeable energy boost, but I did feel more clarity than of late.) He took 1-50mg Tramadol pill which is his usual medication to control his pain. It helped, but only a little. Is he having a Herx reaction? We are both worried about what long term (5+years as necessary) is doing to his liver, body, and mind. He gets different opinions from every doctor he sees to resolve his pain from his injuries. Some say the pain is coming from the disc, some say the pain is coming from the shoulder. Others say surgery, others no surgery. We are desperate. I thought the glutathione could help but am now thinking it isn’t right for him. Any thoughts/help would be appreciated.

    • Leah says:

      Try taking immunocal to boost glutathione levels. It’s the BEST way I have found. It’s a glutathione precursor that has 65 clinical trials and is a prescription. It’s a nutraceutical so you don’t have to get a prescription for it, but you could if that makes sense. It’s credible enough to be in the PDR in other words, but they can’t FORCE you to get a prescription because it’s natural. I’m symptom free from numerous long term chronic illnesses. It’s a God send.

    • prioris says:

      I cured my herniated disc with biocell hyaluronic acid. I think hyaluronic acid is active ingredient. He should take 4-6 tablets on empty stomach with glass of water. It takes 6 weeks to heal. Hyaluronic acid replenishes the synovial fluid. Your friends spinal cord likely has sludgy ha that is depleted and needs to to cleaned up. He should feel better in 2 weeks.

  17. James says:


    I’ve had great experience using the acylated form of glutathione in dosage of 200mg per day. I feel that the healing effects are noticable at a much lower dose in comparison to IV and liposomal. There has been several studies done on Acetyl Glutathione, with results in support of better stability and bioavailability on a cellular level. Would you recommend this over IV and NAC?

  18. Marilyn says:

    Have had Fibromyalgia and Lyme for 32 yrs. Taking S-Acetyl Glutathione 100 mgs. every other day. When taking 100 mgs. daily, I felt happier than in ages, my rosacea disappeared and so did the Beau lines in my fingernails…first time in 30 yrs.! However, I got bruises all over me, and was surprised to find out that glutathione is a strong blood thinner. I cut back to every other day, but now rosacea came back w/ a vengeance, and so did whole body neuropathy, which had been under control for years with R-lipoic acid and benfotiamine. I also take NAC, every other day. I wonder if I am sensitive to sulphur supplements., or somehow do not have the glutathione depletion so common in both Fibromyalgia and Lyme?

  19. Zoya says:

    Thank you for this article! I bought the Nordic Natural formula of 1000mg omega 3, 400 mg glutathione and NAC. Took the pill twice, and both times warmth enveloped me. Has anyone had a side effect of heat? It goes away quickly, but stopped taking the pill till I figure out why I experience warmth all over my body.

  20. candis says:

    I have seen a naturopath who mixes me an IV on my off chemo weeks with gluthathuione, Vit C and B complex. He did tell me that high concentrations without any dilution can be a problem. I have been offered 500 mg or 250 mg and no more. He said that taking too much causes problems so those who are up the higher ranges not feeling well might try dropping the dosage. I am paying about $125 for each IV and do them every two weeks so my dosage is low anyway. IV’s move the substance into the bloodstream immediately so it can be absorbed and I trust my naturopath who has multiple degrees. I believe taking supplements on ones own and experimenting is a mistake because it can mess up your body chemistry. See a naturopath who will direct you properly. Good luck!

  21. haya says:


    what about max one gluthatione accelerator it claims to boost the glutathione about 270%
    because of patented ribose connection to cysteine worth to take it


  22. John says:

    This article is lacking pertinent information. If S-acetyl glutathione is used it is highly bio available for the body. Please have up-to-date information if you’re going to write an article like this.

  23. Jens says:

    Since this chemical is produced by the body as well, will supplementing it long-term lead to the body’s own production to decrease, just like hormones would?

  24. Jayakalana says:

    I’m very dark in skin color it gives me a big stress.ig I get iv glutathione what is the safe dose? And how long should I take?

  25. Fernando says:

    Hello, thanks so much for this post!
    I’ve had great experience using for the last 10 weeks next mix ( IV )
    1200 mg Glutathione
    500 mg Vitamin C
    10 mg Zinc Sulfate
    100 ml Sodium Chloride 0.9%

  26. Amy says:

    Can you take glutathione if you are on sulfasalazine ( an immunosuppressant)? I took spiralina months ago and the next day couldn’t turn my head for a month. I assume I wasn’t detoxing or that the spiralina was too much of a boost to my immune system which I is being suppressed. I want to try glutathione as I heard it helps with arthritis but not sure if it will cause a similar reaction. Please share any comments if possible. Thank you.

  27. Berta says:

    Nice post.
    Our friend was diagnosed with CANCER and his doctor recommended him 30 grams per session Intravenous Vitamin C and MULTIVITA IV (mega dose iv vitamins – similar with Myers Cocktail) from PharmaLife Laboratories Romania.
    We need to purchase Gluthatione!
    Please advice.

    • Carolyn Ryan says:

      I inject 50ml a day. I am thinking I may need to add more. I love Bodhd injections of HCG, etc. and love that I inject them myself. Should I add 50ml more a day?

  28. Davide Bianchini says:

    The reason why you may have felt bad after the IV, is that Glutatathione is a strong chelator of heavy metals, in particular mercury. If you had higher than normal levels of mercury in your body, the glutathione would have disrupted it from the cells and circulated it around the body before (hopefully) being excreted, causing the “herx” like feeling.

  29. Carolyn Opatrny says:

    I inject 50ml a day of Glutathione and inject myself with HCG, etc from Bodhd. I am wondering if I should inject it 2 times per day? It has helped me a lot and I am never sick anymore.

  30. Madhavi Radhe says:

    Good information provided. I remained two and half years in glutathione defficiency that was happened due to wrong treatment. I went to number of doctors and no one found out that it was glutathione deficiency. At last throguh my research on internet, I found it. Taking NAC and L cysteine since 15 days and feeling betterment. Can you provide any suggestion?

  31. Sarah Bollinger says:

    Hi John, this really explained a lot and I appreciate how you simplified everything. I am looking into a similar liposomal glutathione/NAC supplement for my son on the Autism Spectrum, but he is unable to swallow pills. I’ve been reading about the sublingual sprays, topical creams, and liquid forms. Do you have any input about the next best strategy for absorption if someone is unable to take the Nordic Naturals pills you suggest?

  32. Cary says:

    I am trying to detox from statin drug poisoning. Taking many supplements. Getting glutathione IV weekly. The last few times I had a sneezing allergy attack while getting the IV. Other than that no issues. What could be causing that reaction?

  33. R. Hara says:

    Hi John. Your information on glutathione is very informative. Thank you.
    Can you please advise me on the best brand/name of glutathione to use for whitening? I have pigmentation and spots on various large areas of my body and want to improve it from inside out and have read via several different articles glutathione is a miracle when taken internally. I’m also peri-menopausal. I’m taking HRT. Will this affect my glutathione intake? I take Opti MSM which has helped my overall health.

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