|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
There is some evidence that the risk ‘T’ allele of C53410037T in the GCLC gene is associated with impaired clearance of mercury which is a potent oxidant 3.
Mercury is typically eliminated from the body by antioxidants such as glutathione. However, in those carrying the risk ‘T’ allele, who also carry the risk ‘G’ allele of A313G in the GSTP1 gene mercury accumulation was observed.
The authors of the study hypothesize that this is due to reduced glutathione synthesis in the body however no data has yet been provided to demonstrate this.
|Avoid mercury containing foods|
Mercury is known for its toxic effects and so should be largely absent from the majority of food.
However, due to increasing environmental pollution and the ability of mercury to linger in relative plants and animals it is known to bio-accumulate rapidly. Therefore those carrying the risk ‘T’ allele of C53410037T may wish to avoid foods in which bio-magnification of mercury levels has occurred, such as certain fish and other apex predators 4, if they also carry the risk ‘G’ allele of A313G in the GSTP1 gene.
Discuss this information with your doctor before taking any course of action.