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Is Bulletproof Coffee to Blame for Your High LDL?

Bulletproof Coffee High LDL Genetics

Why do some people see an increase in lipid markers on the Bulletproof diet?

Let’s dig in to find out more.

In my previous post, I discussed fats, cholesterol, lipoproteins and their impact on heart health.

For the better part of half a century a high dietary intake of saturated fat and cholesterol was identified as the major cause of heart disease, and a low saturated fat/cholesterol diet was promoted in the west as a result.

Numerous studies have since identified weaknesses with this hypothesis, and as a result, in 2015 the USDA Dietary Guidelines Advisory Committee reversed the long-standing recommendation that people limit dietary cholesterol intake.1

However, dietary cholesterol, as is found in eggs, is not necessarily the same thing as dietary saturated fat, as is found in butter.

Whilst the jury is still out on the relative risks and benefits of saturated or unsaturated fats, numerous diet plans have appeared promoting the benefits of a high fat, low carb diet. In fact, some of the Gene Food diet types are built more in the mold of Bulletproof style diets – the California Keto, Urban Grazer and Mosaic diet types all being good examples.

Background on low carb diets and ketosis

By virtually eliminating carbohydrate intake, the body enters a state of nutritional ketosis; whereby ketone bodies (derived from the breakdown of fat) rather than glucose (derived from carbohydrates) provide the majority of the bodies energy.

The first episode of the Gene Food podcast was devoted to ketogenic diets.

This state has been associated with positive outcomes such as weight loss, improvements in type 2 diabetes and numerous cognitive benefits (although there is no robust data backing up this particular claim). However, it has also been associated with negative impacts such as impaired kidney function and the development of osteoporosis.23

A common association with these diets is replacement of long chain triglycerides with medium chain triglycerides (MCTs). Coconut, palm kernel oil and numerous dairy sources are key dietary sources of MCT, however many people use MCT oil supplements to maximize their intake.

Indeed, John, in a previous post discusses his response to MCT oil supplementation.

What is Bulletproof Coffee?

Well before there was Bulletproof coffee, the Tibetans and other Himalayan cultures, drank Yak butter tea.4 Bulletproof Coffee, as developed by David Asprey, is a spin off of this ancient Himalayan tradition.

The company is one of the major players in the “high fat (MCT), low carb” diet world, albeit in an extreme form. Bulletproof coffee is a cup of coffee made from “upgraded” mycotoxin free beans and supplemented with 1-2 tablespoons of grass-fed (rather than corn fed) unsalted butter and 1-2 tablespoons of a proprietary MCT oil. The added fats, in the form of MCT and butter, increase the blood ketone levels of those who drink it.

Proponents claim that it delivers numerous health and cognitive benefits.

Bulletproof Coffee, hyperlipidemia and LDL

An important question is what does following a “high fat, low carb” diet actually do to the levels of lipids in the blood?

In a meta-analysis of several studies, blood triglyceride levels were decreased by an average 2.2 mg/mL, potentially as triglycerides are being broken down into ketone bodies rather than stored.

Cholesterol (0.9 mg/mL), LDL (0.5 mg/mL) and HDL (0.5 mg/mL) in comparison were all increased in those on high fat, low carb diets.5

Bulletproof LDL case study

There is no data describing the effect of Bulletproof Coffee in a large population, however this report describes a patient presenting with hyperlipidemia (elevated levels of lipids in the blood) after regularly drinking Bulletproof Coffee. Importantly, this man saw an increase in triglycerides, which were not elevated in those on more traditional ketogenic diets.

As I discuss in my previous post, cholesterol and triglycerides require packaging with lipoproteins in order to be transported through the circulatory system. I also discuss that the levels of cholesterol and triglycerides detected in the blood are not harmful of themselves, rather it is how and where these lipids are deposited around the body, a process mediated by lipoproteins.

LDL, and in particular a subset known as small dense LDL (sdLDL), are associated with the development of atherosclerotic plaques on the blood vessel walls. These plaques result in the narrowing of the blood vessels, and if ruptured can result in the rapid development of blood clots leading to a heart attack. HDL is thought of as protective, as rather than binding to blood vessel walls, it carries lipids to the liver where they can be broken down or excreted.6

The meta-analysis of ketogenic diets show a clear benefit. Whilst LDL levels are increased, triglyceride levels are decreased, and HDL levels are increased, which is suggestive of a net benefit. However, for the person reporting hyperlipidemia things are less clear. Whilst HDL is elevated, so too are LDL and triglyceride levels, which may point towards an increased risk of the development of atherosclerotic plaques.

It’s important to note here that this is just a single report, plenty of people report a beneficial effect from drinking Bulletproof Coffee, and lacking a large scale study we cannot draw conclusions as to what effect a high dose of saturated fats has on blood lipid and lipoprotein levels.

Anyone consuming Bulletproof coffee should be monitoring their lipid profiles to watch for spikes in metrics like LDL-P.

But, as I’m sure you can see those with alterations in LDL activity, or those with high baseline levels of LDL, may be at risk if they start on an excessively high fat diet as promoted by Bulletproof Coffee.

Are there any polymorphisms which may associate with elevated levels of LDL and risk of heart disease?

Genetic variants that might not do well on Bulletproof Coffee

To answer my previous question, the answer is yes.

In our diet scoring system, diets like Wayoan, Lean Machine, Vegetarian, Villager and Okinawan are all best served steering clear of Bulletproof coffee and saturated fats in general.

There are numerous polymorphisms which associate with increased levels of LDL.

SNP IDGene(s) of interest within or near associated intervalMajor allele, Minor allele (Risk)
rs6544713
ABCG8
C, T
rs515135
APOB
C, T
rs12740374
CELSR2
G, T
rs3846663
HMGCR
C, T
rs2650000
HNF1A
C, A
rs1501908
TIMD4-HAVCR1
C, G
rs6511720
LDLR
G, T
rs6102059
MAFB
C, T
rs10401969
NCAN
T, C
rs11206510
PCSK9
T, C

Table adapted from: https://www.genome.gov/pages/research/dir/commonvariants30loci.pdf

Taken from my previous post, this table shows several polymorphisms that have an association with increased levels of LDL. Importantly, none were directly correlated with an increased risk of heart disease.

However, it is important to note that these studies were performed on normal populations, not ones supplementing their diet with very high levels of saturated fat. It remains unknown whether the risk alleles result in the production of more LDL regardless of lipid level, or if this would be altered when undertaking a high fat diet. Additionally, it is unknown if there are any functional differences in LDL associated with these polymorphisms which when in association with high blood triglyceride levels may prove harmful to heart health.

Short-term symptoms of Bulletproof coffee

But in this instance we’re talking about longterm heart health, how can we fit the acute reports of a racing heartbeat or heart palpitations that some people report after taking MCT oil or drinking Bulletproof Coffee?

The short answer is, we don’t really know. But there are a couple of hypotheses we can make:

  • By replacing a “nutrient rich” balanced meal, with a high fat, but otherwise “nutrient poor” drink it is highly likely that the body is being deprived of key nutrients/minerals/vitamins etc.
  • As we’ve discussed previously vitamin D is key in regulating calcium uptake. As vitamin D is fat soluble, one possibility is that with increased levels of fat circulating in the bloodstream, there is a concurrent increase in vitamin D in the blood as well. This may in turn trigger a greater increase in calcium absorption, leading to a racing heart or heart palpitations.

Both these hypotheses are just that, and so should be taken with a pinch of salt. Until we can really understand the mechanism which is triggering this effect in some people, we can’t really investigate the possible mechanisms.

Take-Home Message

It’s impossible to say whether Bulletproof Coffee is beneficial or harmful to health without proper large scale scientific studies. Whilst saturated fat and cholesterol may not be the bogeymen we thought they were, and should form part of a healthy balanced diet, the extreme dose associated with Bulletproof Coffee may be of concern.

Those who carry one or more of the risk alleles described above should consider careful monitoring of their blood lipid level before drinking Bulletproof Coffee, or consider less extreme ketogenic diets.

Please share your experiences in the comments section.

Dr. Aaron Gardner

Dr Aaron Gardner is a life-scientist with a strong background in genetics and medical research, and the developing fields of personalized medicine and nutrition. Read his full bio here.

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