Apolipoprotein A-II


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Apolipoprotein A-II (APOA2) is an important protein involved in the transport of lipids throughout the blood, and is encoded for by the APOA2 gene 1. APOA2 is the second most abundant of the HDL particles and therefore plays a key role in regulating HDL levels and overall cholesterol metabolism.

There is one SNP in APOA2 which is associated with poorer HDL outcomes.


Heart Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs5082 a g 30

Risk Description

The ‘G’ allele of the SNP rs5082 in the APOA2 gene is associated with increased levels of  LDLc and an altered LDL:HDL ratio following saturated fat intake, with an especially strong effect seen in those at risk of developing type 2 diabetes 2,3. Interestingly when saturated fat intake was reduced carriers of the ‘G’ allele displayed significantly lowered total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol than A allele carriers.

Nutritional Contraindications:*

IngredientActive IngredientEffect
Saturated Fat

The ‘G’ allele of the SNP rs5082 in the APOA2 is associated with poorer lipid outcomes, especially in individuals at risk of developing type 2 diabetes. However, following a reduction in saturated fat intake lipid metrics improved beyond those carrying the normal ‘A’ allele 2.

Discuss this information with your doctor before taking any course of action.

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