|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)||Major Amino Acid||Minor Amino Acid|
The risk allele ‘C’ of the SNP rs9282861 or G638A in the SULT1A1 gene is associated with a poor response to tamoxifen, a chemothereupeutic drug used to treat breast cancer. It is thought that SULT1A1 activity is increased in those carrying the ‘C’ allele meaning that tamoxifen is targeted for degradation more rapidly 4. Although conflicting studies have shown no effect 5.
While there is little that can be done to combat this effect nutritionally, the knowledge that the ‘C’ allele of SULT1A1 leads to increased activity may explain the findings of several other studies which described elevated gastrointestinal cancer risk in those carrying the ‘C’ allele who consumed diet rich in raw red meat 6,7.
Discuss this information with your doctor before taking any course of action.