|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
The risk ‘A’ allele of rs1219515 in the FGFr2 gene has been associated with reduced serum magnesium levels 2. Magnesium is one of the most important metals involved in cellular and tissue processes and is required for good health. Although only a fraction of the magnesium in the body is present in the blood, it is easy to assay and reductions in the amount of detected magnesium is associated with diabetes, high blood pressure and osteoporosis 3–5.
It is unclear exactly how FGFR2 regulates magnesium levels, but given its role in bone formation and maintenance a link is certainly suggested.
The risk ‘A’ allele of rs1219515 is associated with reduced levels of magnesium in the blood. Therefore supplementation may prove beneficial.
Discuss this information with your doctor before taking any course of action.