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Fibroblast growth factor receptor 2 (FGFR2) is a protein involved in cell division and differentiation and is encoded for by the FGFR2 gene 1. FGFR2 is a very commonly expressed protein found in many cells and tissues throughout the body, acting as a receptor for several members of the FGF family, FGFR2 plays an important role in tissue repair and the development of bone and blood vessels in particular.

One SNP has been identified in the FGFR2 gene which is associated with altered magnesium absorption, and potentially altered bone health rs1219515.


Science Grade
Musculoskeletal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs1219515 g a 4

Risk Description

The risk ‘A’ allele of rs1219515 in the FGFr2 gene has been associated with reduced serum magnesium levels 2. Magnesium is one of the most important metals involved in cellular and tissue processes and is required for good health. Although only a fraction of the magnesium in the body is present in the blood, it is easy to assay and reductions in the amount of detected magnesium is associated with diabetes, high blood pressure and osteoporosis 35.

It is unclear exactly how FGFR2 regulates magnesium levels, but given its role in bone formation and maintenance a link is certainly suggested.

Direct Nutrients:*

Ingredient Active Ingredient Effect

The risk ‘A’ allele of rs1219515 is associated with reduced levels of magnesium in the blood. Therefore supplementation may prove beneficial.

Discuss this information with your doctor before taking any course of action.

  1. https://www.ncbi.nlm.nih.gov/pubmed/2172978
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685389/
  3. https://www.ncbi.nlm.nih.gov/pubmed/10527292/
  4. https://www.ncbi.nlm.nih.gov/pubmed/8017327/
  5. https://www.ncbi.nlm.nih.gov/pubmed/2184830/

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