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Coagulation Factor VIII (factor VIII) is an essential blood clotting protein which is encoded for by the F8 gene. Factor VIII protein circulates in the bloodstream in an inactive form until an injury to the circulatory system occurs. At this point it is activated and then proceeds to bind with other coagulation factors to form a blood clot preventing blood loss 1.

Clinical mutations in this gene are associated with hemophilia, whereby clots do not form correctly and sufferers are at risk of bleeding out, from relatively minor injuries. This severe disorder is usually diagnosed early in life; however, elevated levels of factor VIII are also associated with health issues associated with overactive clot formation such as deep vein thrombosis (DVT) or pulmonary embolisms. These disorders typically occur much later in life and the exact importance of factor VIII is poorly understood 2.


Heart Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs6643714 g a 44

Risk Description

The risk ‘A’ allele of A5219+7398G in the F8 gene is associated with decreased factor VIII activity. However, no clinical outcomes have been associated with this reduced activity and so it is not currently possible to recommend any specific nutritional advice 3.

Discuss this information with your doctor before taking any course of action.


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