|Minor Allele Frequency (%)
|Major Amino Acid
|Minor Amino Acid
Both the ‘A’ and ‘G’ alleles of A1376G in the CETP gene can be thought of as risk alleles. The very rare ‘G’ allele was associated with decreased CETP activity which increased serum HDL levels and also increased the risk of coronary heart disease 2, importantly though this study was performed in a Japanese population so it is not clear if this effect is more widely applicable.
However, the ‘G’ allele may demonstrate a protective benefit against elaidic acid, the major component of trans fats, which is strongly implicated in heart disease 3. Elaidic acid has been shown to increase the activity of CETP, which then somewhat confusingly lowers HDL cholesterol levels 4.
Those carrying the common ‘A’ allele may be more susceptible to the effects of elaidic acid as they feature normal CETP activity, which is increased in its presence. However, the mechanisms are poorly understood and conflict with activities of the ‘G’ allele.
However, trans fats are widely regarded as being of high risk for the development of heart disease, and there are few if any described benefits, therefore omitting them from the diet is strongly recommended for all individuals.
Discuss this information with your doctor before taking any course of action.