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Cadherin EGF LAG Seven-Pass G-Type Receptor 2 (CELSR2) is a protein expressed to the surface of cells and is important in regulating cell communication, it is encoded for by the CELSR2 gene.

The exact function of CELSR2 is unknown however due to its similarity to other proteins it is predicted to play a role in contact mediated cell-to-cell communication, whereby cells can pass messages to their immediate neighbour 1.

Some studies have identified that the SNP rs12740374 or G*919T may be associated with altered blood lipid profiles, through unknown mechanisms.


Science Grade
Heart Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs646776 t c 24

Risk Description

The risk ‘G’ allele of rs646776 in the CELSR2 gene has been associated with an increased risk of coronary artery disease through alterations in circulating LDL-cholesterol levels 2; accounting for approximately 1% of cholesterol variance between individuals, however no mechanism has been described to account for this effect.

Similarly the a single copy of risk ‘G’ allele was shown to reduce statin effectiveness at reducing LDL-cholesterol by 1.3% 3 again through an unknown mechanism.

As the normal function of CELSR2 is unknown and the mechanism linking its action with an altered lipid profile is also unknown it is not possible to describe any nutrient recommendations at the current time.

Discuss this information with your doctor before taking any course of action.


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