|Minor Allele Frequency (%)
The risk ‘G’ allele of rs646776 in the CELSR2 gene has been associated with an increased risk of coronary artery disease through alterations in circulating LDL-cholesterol levels 2; accounting for approximately 1% of cholesterol variance between individuals, however no mechanism has been described to account for this effect.
Similarly the a single copy of risk ‘G’ allele was shown to reduce statin effectiveness at reducing LDL-cholesterol by 1.3% 3 again through an unknown mechanism.
As the normal function of CELSR2 is unknown and the mechanism linking its action with an altered lipid profile is also unknown it is not possible to describe any nutrient recommendations at the current time.
Discuss this information with your doctor before taking any course of action.