|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
The risk ‘C’ allele of rs515135 in the APOB gene has been associated with an increased risk of coronary artery disease in a variety of population screening studies 3,4. In each instance rs515135 was associated with elevated lipid levels, however the studies also reported on multiple other SNPs, so the mechanism remains unclear.
Nattokinase is an enzyme which is extracted and purified from a Japanese food called nattō, which is made from fermented soybeans.
The nattokinase itself is secreted from a bacteria involved in the fermentation process and has a very strong ability to break down blood clots 5, whilst also demonstrating a beneficial effect on blood pressure 6 and general cardiovascular health 7.
As such supplementation may prove beneficial for those carrying the risk ‘C’ allele who are more likely to feature an elevated lipid profile and be at increased risk of clot formation.
Bromelain is extracted from plants of the Bromeliaceae family, such as pineapples. This extract is rich in two enzymes called stem and fruit bromelain which have able to strongly digest blood clots preventing their fomation 8.
Supplementation may therefore prove beneficial to those carrying the risk ‘C’ allele who are more likely to feature an elevated lipid profile with the associated increased risk of clot formation.
Discuss this information with your doctor before taking any course of action.