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Transient Receptor Potential Cation Channel SM6 (TRPM6) is a protein responsible for absorbing magnesium in the kidney and is encoded for by the TRPM6 gene. Magnesium is excreted from the body into urine after passing through the kidney. To prevent an excessive loss of magnesium, TRPM6 can re-absorb magnesium immediately prior to its excretion.

There is one SNP, rs11144134 or A33+2944G, which is associated with poor health outcomes.


Science Grade
Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs11144134 a g 3

Risk Description

The common ‘A’ allele of A33+2944G in the TRPM6 gene is associated with hypomagnesemia, a deficiency of magnesium in the blood 2. Hypomagnesemia is often associated with an increased risk of developing diabetes, high blood pressure and osteoporosis 35.

Mutations in TRPM6 lead to the development of severe hypomagnesemia through a supposed loss of function, meaning magnesium is not reabsorbed correctly 2. It is thought that the ‘A’ allele of A33+2944G produces a similar, although less severe effect.

Direct Nutrients:*

Ingredient Active Ingredient Effect

The risk ‘A’ allele of A33+2944G in the TRPM6 gene is associated with low levels of magnesium in the blood, thought to be associated with reduced reabsorbtion.

Therefore, magnesium supplementation may prevent the occurrence of hypomagnesemia and the associated harmful health effects.

Discuss this information with your doctor before taking any course of action.


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