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Transcription factor 7-like 2 (T-cell specific, HMG-box) or TCF7L2 is a transcription factor which alters the expression of genes related to glucose metabolism in the liver and pancreas, it is encoded for by the TCF7L2 gene1.

In the pancreas, TCF7L2 alters the expression of genes which regulate the synthesis of glucagon, an enzyme which promotes the release of glucose and fatty acids into the bloodstream from the liver. As such it operates in the opposite direction of insulin which promotes cells to uptake glucose and store it for later use2. However, TCF7L2 also regulates many other pathways and so it’s exact effects impacts across different populations are hard to model3.

There is one SNP in TCF7L2 that is associated with an increased risk of developing type-2-diabetes, 53341C>T, although its effects may be population dependent.


Science Grade
Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs7903146 c t 27

Risk Description

The risk ‘T’ allele in the SNP 53341C>T is associated with increased risk of developing type-2-diabetes. This effect was driven by reductions in insulin secretion and increased the production of glucose from the liver, under the control of glucagon. Those carrying two copies of the risk ‘T’ allele demonstrate significantly increased expression of the TCF7L2 protein compared to heterozygotes and carriers of the non-risk “C” allele, suggesting that they may be at heightened risk4,5.


Nutritional Contraindications:*

Ingredient Active Ingredient Effect
High carbohydrate diets/free carbohydrates

The risk “T” allele of the SNP 53341C>T is associated with increased risk of developing type-2-diabetes, as diets containing a high level of carbohydrates, especially free easy to digest carbohydrates such as sugars should be avoided. Where possible complex carbohydrates containing high levels of natural fibers should be preferred.

Discuss this information with your doctor before taking any course of action.


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