|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
The risk ‘T’ allele in the SNP 53341C>T is associated with increased risk of developing type-2-diabetes. This effect was driven by reductions in insulin secretion and increased the production of glucose from the liver, under the control of glucagon. Those carrying two copies of the risk ‘T’ allele demonstrate significantly increased expression of the TCF7L2 protein compared to heterozygotes and carriers of the non-risk “C” allele, suggesting that they may be at heightened risk4,5.
|High carbohydrate diets/free carbohydrates|
The risk “T” allele of the SNP 53341C>T is associated with increased risk of developing type-2-diabetes, as diets containing a high level of carbohydrates, especially free easy to digest carbohydrates such as sugars should be avoided. Where possible complex carbohydrates containing high levels of natural fibers should be preferred.
Discuss this information with your doctor before taking any course of action.