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Interleukin-23 receptor (IL23R) is the receptor for IL-23, a cytokine release by cells to transmit messages, and is encoded for by the IL23R gene. IL-23 was described only relatively recently so its full role and mechanism of action remains poorly understood. IL-23 is thought to be secreted by immune cells in order to generate an inflammatory response, and over activation of IL-23R has been associated with the development of arthritis, psoriasis and intestinal inflammatory diseases including Crohn’s disease.

There is one SNP within the IL23R gene which has been shown to associate with poor health outcomes, rs11209026 or G533A.


Science Grade
Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%) Major Amino Acid Minor Amino Acid
rs11209026 g a 4.5 Arg Gln

Risk Description

The risk ‘G’ allele of G533A within the IL23R gene is associated with an increased risk of developing Crohn’s disease or inflammatory bowel disease (IBD). There are also other less well investigated risks associated with the ‘G’ allele including; ankylosing spondylitis, psoriasis and ulcerative colitis.

Discuss this information with your doctor before taking any course of action.


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