|Minor Allele Frequency (%)
|Major Amino Acid
|Minor Amino Acid
The risk ‘T’ allele of G1208T in the CTH gene has been associated with an accumulation of homocysteine specifically in an ethnic Chinese population 3. However, the authors do not describe a mechanism, although reduced enzyme activity seems the most likely cause, nor have any other groups replicated these findings.
As with CBS vitamin B6 is the co-factor for CTH and is required for its activity. Although it is unclear if the risk ‘T’ allele of G1208T is associated with reduced enzyme activity, ensuring adequate levels of vitamin B6 should maintain enzyme function. An excellent response for CBS SNPs has been observed but not data for CTH has been generated 4.
Discuss this information with your doctor before taking any course of action.