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Dedicator Of Cytokinesis 7


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Dedicator Of Cytokinesis 7 (Dock7) is a protein which is important in the formation and maintenance of neurons which is encoded for by the DOCK7 gene 1.

Dock7 is part of a large class of cell signalling molecules which allow for vital, rapid communication between cells 2. Studies have shown that Dock7 is vital in generating the protective membrane surrounding neurons and also in the generation of new neurons themselves 3,4.


Brain Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs10889353 t g 33

Risk Description

The risk ‘G’ allele of T40844G has been associated with alterations in the blood cholesterol and lipid profile of individuals 5. Given its vital role for neuronal development it is not clear how this SNP can alter lipid profiles. One hypothesis is that lipids which are usually required to maintain the protective coating of neuronal cells are instead released into the blood.

Additionally, although lipid profiles are altered no health impacts have been associated with this SNP.

Discuss this information with your doctor before taking any course of action.

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