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BTBD9 is a genetic marker linked to restless leg syndrome. At Gene Food, we are interested in how BTBD9 plays a role in disordered sleep, and magnesium metabolism.

The BTBD9 gene has been studied in the context of Restless Legs Syndrome (RLS), a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by uncomfortable sensations. Variations in the BTBD9 gene have been linked to an increased risk of developing RLS, and the gene appears to play a role in regulating iron in the brain, which is also associated with RLS.


Science Grade
Brain Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%)
rs3923809 a g 30.9

Risk Description

In a study that evaluated 943 Icelandic individuals using the RLS questionnaire followed by measurement of their periodic limb movements, individuals with the A allele were approximately 1.8 times more prone to experiencing restless legs syndrome than those with the G allele.

The research proposes that around half of restless legs syndrome cases may be associated with the AA and AG genotypes. 1 Keep in mind however, that the A allele is carried by the majority of the population. The G alelle carries lower risk of RLS and is less prevalent. 

Indirect Nutrients:*

Ingredient Active Ingredient Effect

Studies conflict, but some research has shown a link between restless leg syndrome and magnesium deficiency. This UCLA Health overview does a good job of highlighting the role magnesium may play for some people in alleviating symptoms of RLS.

Discuss this information with your doctor before taking any course of action.


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