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Genes Linked to Higher Uric Acid and Gout Risk

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If you’re looking for an explanation for elevated uric acid levels, there are some SNPs that could play a role.

URAT1/SLC22A12

There are a couple of SNPs related to uric acid that are of interest. The first and potentially most interesting are located in the urate transporter 1 (URAT1) gene which is also called SLC22A12.

This protein’s primary function is to regulate the re-absorption of uric acid in the kidneys, so you can see how any changes in function could dramatically alter uric acid levels. In this study, the authors identified three SNPs of real interest rs75786299, rs7929627 and rs3825017.

Of the three the first, rs75786299 (~30 times risk), had by far an away the strongest associated with elevated uric acid in the blood, which would be suggestive of reduced URAT1 activity, with the other two having a lesser but still significant effect on uric acid levels.

Most interestingly a particular combination of the three SNPs, known as a haplotype, showed a much larger (~90 times) risk than any one SNP alone. The individual risks and this haplotype are detailed in the table below. Importantly, whilst this single study showed a strong effect in a Korean population, other studies in Caucasian populations are less clear.1 2

GeneSNPRisk AlleleGout risk (per risk allele)Uric acid effect (per risk allele)
URAT1rs75786299AUnknownx32 risk for hyperuricaemia
rs7929627GUnknownx2 risk for hyperuricaemia
rs3825017TUnknownx2 risk for hyperuricaemia
Combination of aboveA,G,TUnknownx92 risk for hyperuricaemia
ABCG2rs2231142T1.7 xUnknown
rs72552713A2.8 xUnknown
GLUT9rs16890979C1.7 x+ 0.47 mg/dl
rs6449213T2 x+ 0.02 mMol/l
rs12498742A1.25 x (homozygote risk only)Unknown
SLC17A3rs1165205A0.15 xUnknown

ABCG2

There are a couple of other SNPs of interest as well. rs2231142 in the ABCG2 gene is probably the most well known and has a strong association with the development of gout, as does rs72552713 which is also in the ABCG2 gene. AS with URAT1, ABCG2 also functions in the kidney where it functions to export urate into the urine, allowing its excretion.3

The risk allele T of the rs2231142 SNP is very strongly associated with an increased risk of gout, with those homozygous for the risk allele having approximately 3.5 times the risk, and heterozygotes having roughly twice the risk16, an effect which several other studies have supported.4 5

A similar effect for the risk allele A of rs72552713 has also been reported, although there is less supporting evidence in multiple populations.6

GLUT9/SLC2A9

Finally, other SNPs in SLC2A9 rs16890979, rs6449213 and rs12498742 and SLC17A3 rs1165205 have also been associated with an increased risk of gout. SLC2A9, also known as GLUT9 is a major regulator of urate transfer in the kidneys, and so it is unsuprising that SNPs have been identified which increase risk.7 8

Of these, rs16890979 is perhaps the most widely investigated and the risk C allele was associated with approximately a 3.5x increased risk of developing gout, through having serum levels approximately 0.5 mg/dl higher for each copy of the risk allele carried.

Dr. Aaron Gardner, BSc, MRes, PhD

Dr. Aaron Gardner, BSc, MRes, PhD is a life-scientist with a strong background in genetics and medical research, and the developing fields of personalized medicine and nutrition. Read his full bio here.

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