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#08 – The Histamine Leaky Gut Connection with Dr. Aaron Gardner

Histamine. It’s an important neurotransmitter found in the brain, in the gut, and even in the food we eat. Commonly associated with allergy, there’s more to histamine than meets the eye. In this episode of the podcast, we get into all things histamine and histamine intolerance. We discuss the genes that play an important role in clearing histamine from the body, the link between histamine intolerance and leaky gut, how to determine whether your histamine levels have gotten too high, supplements to consider for quieting down the immune system and keeping histamine in check, and whether low histamine diets are sustainable. You can view my histamine intolerance blog here and the American Journal of Clinical Nutrition article referenced in the podcast episode here.

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This Episode Covers:

  • Histamine the neurotransmitter vs. the biogenic amine [7:00];
  • Mast cells and their inflammatory role in the body [9:20];
  • Nerve Growth Factor [20:00];
  • Histamine genes [27:00];
  • Zonulin, leaky gut and histamine [29:00];
  • The anxiety histamine link [36:00];
  • Core factors that contribute to problems with histamine [43:00];
  • Blood type, hydrochloric acid and histamine [53:00];
  • Supplements and nutrients to help with histamine metabolism [59:00];
  • Are low histamine diets healthy? [1:06];
  • It’s not the DAO gene, it’s the AOC1 gene [1:16];

John O'Connor

John O'Connor is the founder of Gene Food, a nutrigenomic startup helping people all over the world personalize nutrition. John is the host of the Gene Food Podcast and a health coach trained at Duke's Integrative Medicine Program. Read his full bio here.

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  1. Eric J Sadler says:

    You mention the “show notes” a few times in this and other podcatsts. How does one access the “show notes?” I cannot find any links.

    Thank you

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