|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
The common ‘A’ allele of A33+2944G in the TRPM6 gene is associated with hypomagnesemia, a deficiency of magnesium in the blood 2. Hypomagnesemia is often associated with an increased risk of developing diabetes, high blood pressure and osteoporosis 3–5.
Mutations in TRPM6 lead to the development of severe hypomagnesemia through a supposed loss of function, meaning magnesium is not reabsorbed correctly 2. It is thought that the ‘A’ allele of A33+2944G produces a similar, although less severe effect.
The risk ‘A’ allele of A33+2944G in the TRPM6 gene is associated with low levels of magnesium in the blood, thought to be associated with reduced reabsorbtion.
Therefore, magnesium supplementation may prevent the occurrence of hypomagnesemia and the associated harmful health effects.
Discuss this information with your doctor before taking any course of action.