NOD2

Protein:

Nucleotide-binding oligomerization domain-containing protein 2


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Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is a receptor protein expressed on immune cells and is encoded for by the NOD2 gene. NOD2 is responsible for recognizing bacterial molecules (peptidoglycans) and and generating an immune response 1.

There are two SNPs within associated with the NOD2 gene and poor health outcomes; rs2066844 or C2104T and rs2066845 or G30491C/T.

C2104T

Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%) Major Amino Acid Minor Amino Acid
rs2066844 c t 4ArgTrp

Risk Description

The risk ‘T’ allele of C2104T in the NOD2 gene is associated with an increased risk of Crohn’s disease and other digestive disorders such as inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS). In those carrying one copy of the ‘T’ allele their risk is increased 3 times, whereas those carrying two copies of the ‘T’ allele are at 35 times the risk of developing Crohn’s disease 24.

It is unclear exactly how this SNP leads to an increased risk of developing Crohn’s disease. However, based on its role in the immune system it seems likely that the ‘T’ allele leads to the formation of a more sensitive NOD2 receptor, which generates an immune response much more readily.

Indirect Nutrients:*

IngredientActive IngredientEffect
Saccharomyces boulardii

Saccharomyces boulardii is a probiotic yeast species with a beneficial impact on digestive health benefiting those who suffer from Crohn’s disease 6 or IBD/IBS 7.

Those carrying the risk ‘T’ allele of C2104T, which is associated with an increased risk of Crohn’s disease, may therefore benefit from supplementing their diet with S. boulardii

Discuss this information with your doctor before taking any course of action.

G30491C/T

Gastrointestinal Health
rsID Number Major Allele Minor Allele Minor Allele Frequency (%) Major Amino Acid Minor Amino Acid
rs2066845 g c 0.7GlyArg

Risk Description

The risk ‘C’ allele of G30491C in the NOD2 gene is associated with an increased risk of Crohn’s disease and other digestive disorders such as IBD/IBS, and also psoriatic arthritis.

It is also possible for G30491T to occur, where ‘T’ also functions as a risk allele, it is unclear if this is to the same extent as the more common ‘C’ risk allele 5.

In those carrying one copy of the ‘C’ allele their risk for developing Crohn’s disease is increased 3 times, whereas those carrying two copies of the ‘C’ allele are at 35 times the risk 24.

It is unclear exactly how this SNP leads to an increased risk of developing Crohn’s disease. However, based on its role in the immune system, and its involvement in the development of psoriatic arthritis it seems likely that the ‘C/T’ allele leads to the formation of a more sensitive NOD2 receptor, which generates an immune response much more readily.

Indirect Nutrients:*

IngredientActive IngredientEffect
Saccharomyces boulardii

S. boulardii is a probiotic yeast species which has been shown to have a beneficial effect on digestive health; especially in those who suffer from Crohn’s disease 6 or IBD/IBS 7.

Those carrying the risk ‘C/T’ allele of G30491T, which is associated with an increased risk of developing Crohn’s disease, may therefore benefit from supplementing their diet with S. boulardii

Discuss this information with your doctor before taking any course of action.

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