The ‘T’ allele of G67+2015T in the LDLR gene is associated with lower levels of circulating LDL cholesterol and therefore a reduced CVD risk 3. However, given the ongoing research into the relative importance of cholesterol, lipids and cholesterol ratios it is currently unclear if this reduction in LDL is beneficial to all.
Whether or not G67+2015T is itself modulates LDLR activity or acts as a marker for some other mechanism remains unknown, although the authors present some preliminary evidence to suggest that LDLR expression is elevated in those carrying the ‘T’ allele.
As such, we currently feel unable to provide direct nutritional advice for this SNP. Rather this SNP should inform your dietary choices based on your current blood lipid results.
Discuss this information with your doctor before taking any course of action.