|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
The risk ‘A’ allele of the SNP A-352T in the IL8 gene is associated with an increased risk of Helicobacter pylori infections in the gut 4. H. pylori infection is associated with numerous risks including an increased risk of stomach ulcers 5, cancers of the digestive system 6 and impaired nutrient absorption 7.
Strong antibiotics are often used to clear H. pylori infections which can result in antibiotic associated diarrhea (AAD). In those who suffer recurrent infections this can impart a large health burden and predisposes suffers to colonisation by other pathogenic organisms such as Clostridium difficile 10.
S. Boulardii supplementation significantly reduced the occurrence of AAD in patients receiving antibiotic therapy for H. pylori infection, maintaining a healthy gut and preventing colonisation by other pathogens 11.
Therefore, those carrying the risk ‘A’ allele of A-352T may benefit from S. Boulardii supplementation.
Discuss this information with your doctor before taking any course of action.