|rsID Number||Major Allele||Minor Allele||Minor Allele Frequency (%)|
The ‘G’ allele of the SNP rs5082 in the APOA2 gene is associated with increased levels of LDLc and an altered LDL:HDL ratio following saturated fat intake, with an especially strong effect seen in those at risk of developing type 2 diabetes 2,3. Interestingly when saturated fat intake was reduced carriers of the ‘G’ allele displayed significantly lowered total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol than A allele carriers.
The ‘G’ allele of the SNP rs5082 in the APOA2 is associated with poorer lipid outcomes, especially in individuals at risk of developing type 2 diabetes. However, following a reduction in saturated fat intake lipid metrics improved beyond those carrying the normal ‘A’ allele 2.
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