Category

MTHFR

B12, B6, B9

B vitamin supplements and cancer risk: how to make smart decisions

You might have come across some articles discussing an association between B vitamins and an increased cancer risk. Given how fundamental B vitamins are to some of our major focus genes, think MTHFR, CBS, SHMT, MTR, we thought this was a topic worth diving into. In addition, and putting nutrigenomics and this blog aside, we… Read More

Malabsorption Nutrients Genetic

5 common genetic variations that affect nutrient absorption

Nutrigenetics is the branch of nutrigenomics focusing on how genetic variations affect nutrient absorption, use, and metabolism. Nutrigenetics research typically focuses on a type of genetic variation known as a single nucleotide polymorphism, or SNP. Each of our genes is made up of four nucleotides arranged in a specific pattern. When one of the four… Read More

Vitamin B12 Shots

My experience with Vitamin B12 shots

For those playing along at home with their 23andme data, I am heterozygous (A/G) for MTRR rs1801394. I was hesitant for this rite of passage. In what sort of world did a newer team member of a company get a shot of B vitamins injected into their backside to be an official part of the… Read More

COMT MTHFR

Are the COMT and MTHFR genes linked?

Two of the most talked about genes in relation to nutrigenomics and health are MTHFR and COMT. Indeed these two genes are frequently discussed together by individuals and healthcare professionals (R). Partly this is because of well investigated and characterized polymorphisms such as C667T for MTHFR, or G472A for COMT, with described health impacts, but… Read More

High Homocysteine Levels

7 genes linked to high homocysteine levels and what to do about them

Homocysteine is a vital molecule required for numerous processes within the cells of our body to ensure good health. However, as with much in life, sometimes you can have too much of a good thing. When present at elevated levels homocysteine is associated with numerous poor health outcomes including; increased cardiovascular risk (R,R), increased risk… Read More

MTHFR Mutations

The science of MTHFR mutations explained

Updated April 28th, 2017 If you’re interested in personalized genetic medicine you will have undoubtedly come across the protein methylenetetrahydrofolate reductase (MTHFR). MTHFR is an enzyme which is encoded by the MTHFR gene and functions to convert 5,10-methylenetetrahydrofolate (MeTHF) to 5-methlytetrahydrofolate (MTHF). What sounds like a pretty un-inspiring reaction has actually become one of, if… Read More

B Vitamins Role Genetics

Meet your B vitamins

In this post I’m going to look at the B vitamins in nutrition and health. But let’s take a step back and actually look at what a vitamin is, and isn’t. In order to be defined as a vitamin, a molecule must meet four criteria. A vitamin must be an organic compound, very simply this… Read More

MTHFR Mutation Test

Do I have an MTHFR mutation? Here’s how to find out

Updated November 20th, 2017  Summary: Everyone has an MTHFR gene in one form or another. An MTHFR “mutation” means you inherited an MTHFR variant associated with a decreased ability to metabolize folic acid and folate. In some cases, people with MTHFR mutations benefit from supplementing with methylfolate, which is the “bioactive” form of folate. This “gets… Read More

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